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The naked mole-rat Heterocephalus glaber is one of the most Daemon aranda wife sexual dysfunction models used to study genome maintenance systems, including the effective repair of damage to DNA.

The naked mole-rat is the longest lived rodent species, which is extraordinarily resistant to cancer and has a number of other unique phenotypic traits. The naked mole-rat draws the heightened attention of researchers who study the molecular basis of lengthy lifespan and cancer resistance. Despite the fact that the naked mole-rat lives under genotoxic stress conditions oxidative, etc. The unique traits of phenotypic and molecular adaptations found in the naked mole-rat speak to a high stability and effective functioning of the molecular machinery that counteract damage accumulation in its genome.

This review analyzes existing results in the study of the molecular basis of longevity and high cancer resistance in naked mole-rats. Extreme hypoxia tolerance of naked mole-rat brain. Mammalian brains have extremely high levels of aerobic metabolism and typically suffer irreversible damage after brief periods Daemon aranda wife sexual dysfunction oxygen deprivation such as occur during stroke or cardiac arrest.

Here we report that brain tissue from naked mole-ratsrodents that live in a chronically low-oxygen environment, is remarkably resistant to hypoxia: We suggest that brain tolerance to hypoxia may result from slowed or arrested brain development in these extremely long-lived animals. High molecular weight hyaluronan mediates the cancer resistance of the naked mole-rat. The naked mole-rat displays exceptional longevity, with a maximum lifespan exceeding 30 years 1—3.

This is the longest reported lifespan for a rodent species and is especially striking considering the small body mass of the naked mole-rat.

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In comparison, a similarly sized house mouse has a maximum lifespan of 4 years 4,5. In addition to their longevity, naked mole-rats show an unusual resistance to cancer.

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