Medically reviewed on Jun 7, Commonly reported side effects of selegiline include: Other side effects include: See below for a comprehensive list of adverse effects. Along with its needed effects, selegiline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the Selegiline sexual side effects side effects occur while taking selegiline:.
Get emergency help immediately if any of the following symptoms of overdose occur while taking selegiline: Some side effects of selegiline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the "Selegiline sexual side effects." Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.
For Healthcare Professionals Applies to selegiline: In prospective pre-marketing studies, the most commonly reported side effects leading to treatment discontinuation with selegiline oral tablets were, in decreasing order of frequency, nausea, hallucinations, confusion, depressionloss of balanceinsomniaorthostatic hypotensionincreased akinetic involuntary movements, agitation, arrhythmiabradykinesia, chorea, delusions, hypertension, new or increased pectorisand syncope.
In clinical trials with selegiline orally disintegrating tablets, the most commonly reported side effects leading to treatment discontinuation were dizziness, chest pain, accidental injury, and myasthenia. The relative risk for treatment-emergent hypertension and orthostatic or postural hypotension was reported as being at least 2 fold greater in patients 65 years or older compared to those younger than 65 years.
Patients over 65 years were also reported at an increased risk for somnolence compared to younger patients. Selegiline potentiates the effects of levodopa ; therefore, the side effects of levodopa may be emphasized unless the levodopa dose is reduced. Insomnia and sleep disorder were reported as very common side effects with selegiline in double-blind placebo-controlled clinical trials at a higher frequency when used as adjunctive therapy with levodopa in the earlier phases of Parkinson's disease.
Insomnia was also reported as a very common side effect in placebo-controlled clinical trials for major depressive disorder with transdermal selegiline. There have been very few cases reported with selegiline. In some cases, dose reduction or treatment discontinuation led to cessation of impulse control disorders. Postmarketing reports have indicated that patients taking this drug may experience new or worsening mental status and behavioral changes, such as psychotic-like behavior, particularly after starting therapy or increasing the dose.
Certain medications used to treat psychosis e. Transient high and bruxism were reported at doses greater than 10 mg per day.
Anxiety was reported as a very common side effect with selegiline in double-blind placebo-controlled clinical trials when used as adjunctive therapy with levodopa in the earlier phases of Parkinson's disease. Antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment.
An increased risk of suicidal thinking and behavior in children, adolescents, and young adults aged 18 to 24 years with major depressive disorder MDD and other psychiatric disorders has been Selegiline sexual side effects with short-term use of antidepressant drugs. Adult and pediatric patients receiving antidepressants for MDD, as well as for psychiatric and nonpsychiatric indications, have reported symptoms that may be precursors to emerging suicidality, including anxiety, agitation, panic attacksinsomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, Selegiline sexual side effectsand mania.
Causality has not been established. Abnormal dreams, agitation, manic reaction, mild transient irritability, mood change, psychoses. Abnormal thinking, aggressive reaction, bruxism, delirium, impulse control disorders and compulsions, nervousness, paranoid reaction, paroniria, psychotic-like behavior [ Ref ].
There have been reports of falling asleep while engaged in activities of daily Selegiline sexual side effects, including the operation of motor vehicles, which sometimes resulted in accidents, in Parkinson's disease patients treated with this drug. These reports have occurred in a setting of pre-existing somnolence. Impaired memory and myoclonic jerks were reported at doses greater than 10 mg per day. Seizure in dialyzed chronic renal failure in a patient treated with selegiline on concomitant medications has been reported in postmarketing experience.
A symptom complex resembling the neuroleptic malignant syndrome, with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in, antiparkinson therapy. There have been postmarketing reports of fatal and non-fatal cases of serotonin syndrome with concomitant use of this drug with antidepressants.
Headache was reported as a very common side effect in placebo-controlled clinical trials for major depressive disorder with transdermal selegiline.
This drug inhibits the catabolism of dietary amines such as tyramine, and has the potential to produce a hypertensive crisis following the ingestion of tyramine-rich foods or beverages. Postural hypotension was reported with selegiline in double-blind placebo-controlled clinical trials at a higher frequency when used as adjunctive therapy with levodopa in the earlier phases of Parkinson's disease to the late phase.
Palpitation was also reported as a very common side effect in the earlier phases of Parkinson's disease in these trials. Arrhythmia, bradycardiachest pain, hypertension, edemapalpitations. Angina pectoris, ankle edema, orthostatic hypotension, supraventricular tachycardia.
Peripheral edema, hematoma, tachycardia. Flushing, myocardial infarction [ Ref ]. Constipation was reported as a very common side effect with selegiline in double-blind placebo-controlled clinical trials when used as adjunctive therapy with levodopa in the earlier phases of Parkinson's disease.
Vertigo was a very common side effect reported with selegiline in double-blind placebo-controlled clinical trials when used as adjunctive therapy with levodopa compared with its use as monotherapy. Chills, generalized ache, falling down, freezing, heavy leg, increased energy, Selegiline sexual side effects, tinnitustiredness, weakness.
Asthenia, death, fever [ Ref ].
Hair lossskin eruptions. Facial hair, photosensitivity [ Ref ]. Skin disorders reported with this drug have included skin ulcer, fungal dermatitis, skin hypertrophy, contact dermatitisherpes simplex, dry skin, sweating, urticariaand pruritus.
Transient anorgasmia and decreased penile sensation were reported at doses greater than 10 mg per day.
The estimates of the incidence of untoward sexual experience and performance may also underestimate their actual incidence, partly because patients and physicians may be reluctant to discuss this issue. Leucocytopenia, thrombocytopenia [ Ref ]. Transient increase in liver enzyme values [ Ref ].
Application site reactions transdermal patch [ Ref "Selegiline sexual side effects." Application site reactions with the transdermal patch were primarily described as erythema and resolved spontaneously with no treatment.